Two sample MR report
Body mass index (adult) against Coronary heart disease || id:ieu-a-9
Date: 21 September, 2021
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.1528190 | 0.4144168 | 0.7249710 |
| Weighted median | 8 | 0.3548325 | 0.1086720 | 0.0010940 |
| Inverse variance weighted | 8 | 0.3384146 | 0.0776147 | 0.0000130 |
| Simple mode | 8 | 0.4194555 | 0.1515879 | 0.0278109 |
| Weighted mode | 8 | 0.3700897 | 0.1578383 | 0.0514846 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.440915 | 6 | 0.6172335 |
| Inverse variance weighted | 4.648773 | 7 | 0.7027363 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0111951 | 0.0245551 | 0.6644868 |
Test that the exposure is upstream of the outcome
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Note - R2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
